You can configure the I/O directed to the device target based on your Linux version.
Accessing NVMe volumes for virtual device targets
For RHEL 7 and SLES 12, I/O is directed to virtual device targets by the Linux host. DM-MP manages the physical paths underlying these virtual targets.
Accessing NVMe volumes for physical NVMe device targets
For SLES 15, I/O is directed to the physical NVMe device targets by the Linux host. A native NVMe multipathing solution manages the physical paths underlying the single apparent physical device displayed by the host.