Microsoft cluster support limitations when using FC/iSCSI RDM LUNs

The Plug-in for Windows supports Microsoft clusters using FC/iSCSI RDM LUNs on different virtual machines belonging to different ESX or ESXi servers.

Note: This feature is not supported in releases before ESX 5.5i.

The Plug-in for Windows does not support clusters on ESX iSCSI and NFS datastores.
The Plug-in for Windows does not support mixed initiators in a cluster environment.
Initiators must be either FC or Microsoft iSCSI, but not both.
ESX iSCSI initiators and HBAs are not supported on shared disks in a Microsoft cluster.
The Plug-in for Windows does not support virtual machine migration with vMotion if the virtual machine is part of a Microsoft cluster.
The Plug-in for Windows does not support MPIO on virtual machines in a Microsoft cluster.