This document provides the architecture and design of a virtual desktop infrastructure for up to 6000 end-user computing users. The solution is virtualized on fifth-generation Cisco UCS B200 M5 blade servers, booting VMware vSphere 7.01 Update 1 through FC SAN from the AFF A400 storage array. The virtual desktops are powered using Citrix Provisioning Server 1912 LTSR and Citrix RDS/Citrix Virtual Apps & Desktops 1912 LTSR, with a mix of RDS-hosted shared desktops (6000), pooled and/or non-persistent-hosted virtual Windows 10 desktops (5000), and persistent-hosted virtual Windows 10 desktops provisioned with Citrix Machine Creation Services (5000) to support the user population. Where applicable, the document provides best-practice recommendations and sizing guidelines for customer deployments of this solution.