This document provides a reference architecture, design guide, and deployment for up to a 5000-seat, mixed workload end-user computing environment on FlexPod Datacenter with Cisco UCS and NetApp All Flash FAS (AFF) A300 storage. The solution includes VMware Horizon server-based Remote Desktop Server Hosted sessions, VMware Horizon persistent Microsoft Windows 10 virtual desktops, and VMware Horizon non-persistent, Microsoft Windows 10 instant clone virtual desktops on VMware vSphere 6.5.