You must configure the storage timeout intervals per the recommended settings for Storage Replication Adapter (SRA) to perform optimally in highly scaled environments.
See VMware documentation for more information on modifying Storage Provider settings.
VMware vSphere Documentation: Change Storage Provider Settings
You must set the value of the storage.commandTimeout timeout interval for highly scaled environments to 12,000 seconds.
VMware documentation on modifying SAN Provider settings has more information.
Vmware Site Recovery Manager Documentation: Change Storage Settings