This document provides a reference architecture and design guide for a 5000-seat to 6000-seat desktop workload end-user computing environment on FlexPod Datacenter with Cisco UCS and NetApp AFF A300 and NetApp ONTAP data management software. The solution includes VMware Horizon server-based RDS Windows Server 2019 sessions, VMware Horizon persistent, full clone Microsoft Windows 10 virtual desktops, and VMware Horizon non-persistent, instant-clone Microsoft Windows 10 virtual desktops on VMware vSphere 6.7 U2.